Skin Ceuticals A.G.E. Interrupter Advanced

A.G.E. Interrupter Advanced is a potent corrective cream treatment that helps reverse visible signs of aging impacted by collagen decline and glycation, including wrinkles, laxity, and dullness.

This next-generation anti-aging cream is formulated with 18% concentrated Proxylane (+20% more active than previous A.G.E. Interrupter), 4.25% Wild Fruit Flavonoid blend (+12.5% more active), and new ingredients such as 0.1% Glycyrrhetinic Acid. This advanced technology is clinically shown to reduce the look of five types of wrinkles (forehead wrinkles, glabellar line, crow’s feet, nasolabial folds, and marionette lines), restore the skin's firmness & elasticity, and enhance skin's radiance.

Ingredients

  • 18% Concentrated Proxylane
  • 4.25% Wild Fruit Flavonoids
  • 0.1% Glycyrrhetinic Acid
  • 3% Hepes
  • 1% Niacinamide
Full ingredient list
Aqua / Water, Hydroxypropyl Tetrahydropyrantriol, Glycerin, Propylene Glycol, Stearic Acid, Butyrospermum Parkii Butter / Shea Butter, Hydroxyethylpiperazine Ethane Sulfonic Acid, Palmitic Acid, Pentylene Glycol, Oleyl Alcohol, Arachidyl Alcohol, Myristyl Myristate, Panthenol, Niacinamide, Dimethicone, Isononyl Isononanoate, Bis-Peg/Ppg-16/16 Peg/Ppg-16/16 Dimethicone, Glyceryl Stearate, Candelilla Cera / Candelilla Wax, Behenyl Alcohol, Peg-100 Stearate, Sodium Polyacrylate, Pentaerythrityl Tetraisostearate, 4-T-Butylcyclohexanol, Arachidyl Glucoside, Caprylyl Glycol, Xanthan Gum, Chlorphenesin, Myristic Acid, Caprylic/Capric Triglyceride, Glycyrrhetinic Acid, Parfum / Fragrance, Sorbitol, Vaccinium Myrtillus Fruit Extract, Potassium Hydroxide, Adenosine, Citric Acid, Punica Granatum Fruit Extract, Limonene, Coumarin, Linalool, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Best for

Skin Ceuticals A.G.E. Interrupter Advanced is best for: Combination, Dry, Normal, Sensitive

How to use

Morning and evening, smooth a thin, even layer of A.G.E. Interrupter Advanced anti-wrinkle cream across the full face, neck, and chest, massaging gently into the skin. In your AM routine, layer it after a SkinCeuticals vitamin C antioxidant serum and finish with sunscreen; at night, if your regimen includes a retinol, apply this cream as the step that follows it.

Clinical Results

14%Reduction in global fine lines
11.5%Reduction in forehead wrinkles
11%Reduction in nasolabial folds
7%Reduction in marionette wrinkles
7%Reduction in glabellar wrinkles
7%Reduction in crow's feet lines
Protocol
A 12-week, single-center, clinical study was conducted on 77 females with Fitzpatrick type I-VI, ages 35-75, and mild to moderate global wrinkles, fine lines, laxity, rough skin texture, uneven skin tone, and a dull complexion. A.G.E. Interrupter Advanced was used twice daily over face, neck, and chest in conjunction with a sunscreen for 12 weeks. Efficacy and tolerance evaluations were conducted at baseline, weeks 4, 8, and 12.

Product Images

Skin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter AdvancedSkin Ceuticals A.G.E. Interrupter Advanced

Before & After

Before 1 After 1

Reviews

4 ★★★★★ 1074 reviews · as of August 2026
What SkinCeuticals customers report
  • Deep wrinkles and creases visibly softened
  • Rich, all-day hydration without heaviness or grease
  • Noticeably firmer skin
  • Face, neck, chest, and even under-eye versatility

Reviews from SkinCeuticals, not BelleSkin customers.

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Skin Ceuticals A.G.E. Interrupter Advanced
$235.00